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Anticancer potential of NSAID-derived tris(pyrazolyl)methane ligands in iron(II) sandwich complexes.
- Source :
- Dalton Transactions: An International Journal of Inorganic Chemistry; 8/28/2024, Vol. 53 Issue 32, p13503-13514, 12p
- Publication Year :
- 2024
-
Abstract
- Tris(pyrazolyl)methane (tpm), 2,2,2-tris(pyrazolyl)ethanol (tpm<superscript>OH</superscript>) and its esterification derivatives with ibuprofen and flurbiprofen (tpm<superscript>IBU</superscript> and tpm<superscript>FLU</superscript>) were used as ligands to obtain complexes of the type [Fe(tpm<superscript>X</superscript>)<subscript>2</subscript>]Cl<subscript>2</subscript> (1–4). The tpm<superscript>IBU</superscript> and tpm<superscript>FLU</superscript> ligands and corresponding complexes 3 and 4 were characterized by IR and multinuclear NMR spectroscopy, and the structure of tpm<superscript>IBU</superscript> was elucidated by single crystal X-ray diffraction. Complexes 1–4 were also assessed for their behaviour in aqueous media (solubility in D<subscript>2</subscript>O, octanol/water partition coefficient, stability in physiological-like conditions). The antiproliferative activity of ligands and complexes was determined on A2780, A2780cis and A549 cancer cell lines and the non-cancerous HEK 293T and BJ cell lines. The ligands and complexes were investigated for their ability to inhibit COX-2 (cyclooxygenase) and HNE (4-hydroxynonenal) enzymes. Complexes 3 and 4 exhibited cytotoxicity that may be attributed predominantly to their bioactive fragments, while DNA binding and enhancement of ROS production do not appear to play any significant role. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14779226
- Volume :
- 53
- Issue :
- 32
- Database :
- Complementary Index
- Journal :
- Dalton Transactions: An International Journal of Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 178994017
- Full Text :
- https://doi.org/10.1039/d4dt00920g