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A dual DNA-binding conjugate that selectively recognizes G-quadruplex structures.
- Source :
- Chemical Communications; 8/25/2024, Vol. 60 Issue 66, p8744-8747, 4p
- Publication Year :
- 2024
-
Abstract
- G-quadruplex (G4) structures play roles in various biological processes, but the challenge lies in specific targeting. To address this, we synthesized a conjugate capable of recognizing the G4 structure and its proximal duplex. Our conjugate can enable recognition of specific G4s in the human genome to understand and target those structures. [ABSTRACT FROM AUTHOR]
- Subjects :
- HUMAN genome
QUADRUPLEX nucleic acids
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 60
- Issue :
- 66
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 178993910
- Full Text :
- https://doi.org/10.1039/d4cc01572j