Back to Search Start Over

A dual DNA-binding conjugate that selectively recognizes G-quadruplex structures.

Authors :
Ooga, Mitsuharu
Sahayasheela, Vinodh J.
Hirose, Yuki
Sasaki, Daisuke
Hashiya, Kaori
Bando, Toshikazu
Sugiyama, Hiroshi
Source :
Chemical Communications; 8/25/2024, Vol. 60 Issue 66, p8744-8747, 4p
Publication Year :
2024

Abstract

G-quadruplex (G4) structures play roles in various biological processes, but the challenge lies in specific targeting. To address this, we synthesized a conjugate capable of recognizing the G4 structure and its proximal duplex. Our conjugate can enable recognition of specific G4s in the human genome to understand and target those structures. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13597345
Volume :
60
Issue :
66
Database :
Complementary Index
Journal :
Chemical Communications
Publication Type :
Academic Journal
Accession number :
178993910
Full Text :
https://doi.org/10.1039/d4cc01572j