RE: Dietary interventions in cancer: a systematic review of all randomized controlled trials.

A meta-analysis of 252 studies conducted between 1997 and 2023 on dietary interventions in cancer patients found that the majority of these studies focused on feasibility, adherence to diet, weight and body composition, or translational endpoints rather than primary endpoints related to dietary interventions and cancer outcomes. Only 20 trials had a primary endpoint designed to detect an improvement in cancer outcomes, and of those, only 8 met their primary endpoint. However, many of the studies that met their endpoint lacked power calculations, and the remainder failed to meet their enrollment criteria. The review did not account for behavioral factors or engagement levels of the interventions, and did not assess the risk of bias. The study suggests that more rigorous research is needed in this area to determine the impact of dietary changes on cancer outcomes. [Extracted from the article]