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Association between educational attainment and thyroid cancer: evidence from a univariable and multivariable Mendelian randomization study.
- Source :
- Endocrine (1355008X); Sep2024, Vol. 85 Issue 3, p1238-1243, 6p
- Publication Year :
- 2024
-
Abstract
- Background: Thyroid cancer and educational attainment have been related in observational studies. It is unclear if these correlations indicate causative relationships. Methods: Using large-scale genome-wide association studies (GWAS) datasets, we conducted an univariable and multivariable Mendelian randomization (MR) study to assess a potential connection between educational attainment and thyroid cancer. The inverse-variance weighted (IVW) analysis method is used as our primary outcome. Additionally, we carry out several sensitivity analyses to evaluate the pleiotropy and robustness of the causal estimates. Results: Univariate MR study shows 4.2 years of additional education is associated with a 41.4% reduction in thyroid cancer risk (OR = 0.586; 95% CI: 0.378–0.909; P = 0.017). Further multivariable MR analysis revealed that body mass index (BMI) acted as a partial mediating factor in the protective impact of higher educational attainment against thyroid cancer. Conclusion: This MR study provided genetic evidence that longer education attainment is related to a lower risk of thyroid cancer. Strategies of expanding education may reduce the burden of thyroid cancer in the world. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1355008X
- Volume :
- 85
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Endocrine (1355008X)
- Publication Type :
- Academic Journal
- Accession number :
- 178970459
- Full Text :
- https://doi.org/10.1007/s12020-024-03796-2