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Self-Assembly of Hydrophobic Hyperbranched PLMA Homopolymer with –COOH End Groups as Effective Nanocarriers for Bioimaging Applications.

Authors :
Gerardos, Angelica Maria
Foryś, Aleksander
Trzebicka, Barbara
Pispas, Stergios
Source :
Polymers (20734360); Aug2024, Vol. 16 Issue 15, p2166, 19p
Publication Year :
2024

Abstract

Nanomedicine is a discipline of medicine that applies all aspects of nanotechnology strategies and concepts for treatment and screening possibilities. Synthetic polymer nanostructures are among the many nanomedicine formulations frequently studied for their potential as vectors. Bioimaging is a valuable diagnostic tool, thus, there is always a demand for new excipients/nanocarriers. In this study, hydrophobic hyperbranched poly(lauryl methacrylate) (PLMA) homopolymers comprised of highly hydrophobic LMA moieties with –COOH polar end groups were synthesized by employing reversible addition-fragmentation chain transfer (RAFT) polymerization. Ethylene glycol dimethacrylate (EGDMA) was utilized as the branching agent. End groups are incorporated through the RAFT agent utilized. The resulting amphiphilic hyperbranched polymer was molecularly characterized by size exclusion chromatography (SEC), Fourier transformation infrared spectroscopy (FT–IR), and <superscript>1</superscript>H–NMR spectroscopy. Pyrene, curcumin, and IR-1048 dye were hydrophobic payload molecules successfully encapsulated to show how adaptable these homopolymer nanoparticles (prepared by nanoprecipitation in water) are as dye nanocarriers. This study demonstrates a simple way of producing excipients by generating polymeric nanoparticles from an amphiphilic, hyperbranched, hydrophobic homopolymer, with a low fraction of polar end groups, for bioimaging purposes. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20734360
Volume :
16
Issue :
15
Database :
Complementary Index
Journal :
Polymers (20734360)
Publication Type :
Academic Journal
Accession number :
178952865
Full Text :
https://doi.org/10.3390/polym16152166