Silicone Wire Embolization-induced Acute Retinal Artery Ischemia and Reperfusion Model in Mouse: Gene Expression Provides Insight into Pathological Processes (Updated July 31, 2024).

A recent preprint abstract discusses the development of a mouse model for simulating retinal artery occlusion (RAO), a condition that can lead to vision loss. The researchers used silicone wire embolization combined with carotid artery ligation to create a unilateral pterygopalatine ophthalmic artery occlusion (UPOAO) mouse model. They evaluated the survival of retinal ganglion cells and visual function to determine the duration of ischemia. The model successfully replicated the acute interruption of retinal blood supply observed in RAO and revealed various pathophysiological processes related to immune cell migration, oxidative stress, and immune inflammation. This model could be a valuable tool for further research and therapeutic development in RAO. [Extracted from the article]