Patent Application Titled "System And Methods For Insertion And Editing Of Large Nucleic Acid Fragments" Published Online (USPTO 20240247257).

The patent application titled "System And Methods For Insertion And Editing Of Large Nucleic Acid Fragments" introduces a new method called Grand Editing, which allows for the targeted insertion of larger DNA fragments using a gene editor called Prime editing. The inventors have developed a pair of guide RNAs that serve as a template for inserting a large exogenous sequence into the target genomic locus. This method has potential applications in gene therapy and fundamental research. The patent application provides detailed information on the method and its various embodiments, making it a valuable resource for those interested in genome editing and its potential applications in biotechnology and gene therapy. [Extracted from the article]