Overcrowding Drives Tumor Invasion by Inducing Nanotopographical Transition of Plasma Membrane.

According to a preprint abstract, overcrowding in tumor cells can lead to increased invasiveness. Researchers found that overcrowded cancer cells were more abundant in invasive areas in both human cancer samples and mouse models. Through mechanical modeling, genetic manipulations, and biophysical measurements, the study revealed that prolonged overcrowding triggers a nanocorrugated topographic transition of the plasma membrane, which promotes tumor invasion. By suppressing this transition, tumor cell invasion can be resisted. However, it is important to note that this research has not yet undergone peer review. [Extracted from the article]