Unveiling Endoglin non canonical regulation: spotlight on the new role of the uPAR pathway (Updated July 26, 2024).

This article discusses a preprint abstract that focuses on the role of Endoglin, a transmembrane glycoprotein, in endothelial cell biology. The study explores the molecular origins of Hereditary Hemorrhagic Telangiectasia (HHT), a condition caused by loss-of-function ENG variants. The researchers propose an in silico analysis of ENG single nucleotide variants that could lead to Endoglin deficiency and experimentally confirm the association between uPAR and Endoglin in endothelial cells. The study provides new insights into Endoglin molecular determinants, which could potentially improve the management of HHT and other diseases involving Endoglin. It is important to note that this preprint has not been peer-reviewed. [Extracted from the article]