Researchers Submit Patent Application, "Nucleic Acid Sequencing Method And System Employing Enhanced Detection Of Nucleotide-Specific Ternary Complex Formation", for Approval (USPTO 20240247305).

A patent application has been submitted by Corey M. Dambacher for a nucleic acid sequencing method and system that enhances the detection of nucleotide-specific ternary complex formation. The method involves contacting a primed template nucleic acid with a reaction mixture containing a DNA polymerase and a test nucleotide, and measuring the binding of the nucleic acid to the polymerase. This method aims to improve the accuracy and read-length of nucleic acid sequencing across different platforms. The patent application was filed by Pacific Biosciences of California Inc. and addresses the need for extended sequencing read-length with improved base-calling accuracy. [Extracted from the article]