Research from Hainan University Provides New Data on Alzheimer Disease (Impaired Mitochondrial Energy Metabolism Regulated by p70S6K : A Putative Pathological Feature in Alzheimer's Disease).

A study conducted by researchers at Hainan University in China explores the potential relationship between impaired mitochondrial energy metabolism and p70 ribosomal protein S6 kinase (p70S6K) in Alzheimer's disease (AD). The researchers used bioinformatics methods to analyze transcriptomic data from patients with AD and Ab42-treated cells. They found that impaired mitochondrial energy metabolism is a potential pathological feature of AD and that p70S6K gene silencing reversed many of the changes induced by Ab42. This study provides new insights into the role of mitochondrial dysfunction in AD and highlights the potential therapeutic target of p70S6K. [Extracted from the article]