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Short‐term outcomes of endoscopic resection for colorectal neuroendocrine tumors: Japanese multicenter prospective C‐NET STUDY.

Authors :
Ito, Sayo
Hotta, Kinichi
Sekiguchi, Masau
Takeuchi, Yoji
Oka, Shiro
Yamamoto, Hironori
Shinmura, Kensuke
Harada, Keita
Uraoka, Toshio
Hisabe, Takashi
Sano, Yasushi
Kondo, Hitoshi
Horimatsu, Takahiro
Kikuchi, Hidezumi
Kawamura, Takuji
Nagata, Shinji
Yamamoto, Katsumi
Tajika, Masahiro
Tsuji, Shigetsugu
Kusaka, Toshihiro
Source :
Digestive Endoscopy; Aug2024, Vol. 36 Issue 8, p942-951, 10p
Publication Year :
2024

Abstract

Objectives: The incidence of colorectal neuroendocrine tumors (NETs) has increased with colorectal cancer screening programs and increased colonoscopies. The management of colorectal NETs has recently shifted from radical surgery to endoscopic resection. We aimed to evaluate the short‐term outcomes of various methods of endoscopic resection for colorectal NETs. Methods: Among those registered in the C‐NET STUDY, patients with colorectal NETs who underwent endoscopic treatment as the initial therapy were included. Short‐term outcomes, such as the en bloc resection rate and R0 resection (en bloc resection with tumor‐free margin) rate, were analyzed based on treatment modalities. Results: A total of 472 patients with 477 colorectal NETs received endoscopic treatment. Of these, 418 patients with 421 lesions who met the eligibility criteria were included in the analysis. The median age of the patients was 55 years, and 56.9% of them were men. The lower rectum was the most commonly affected site (88.6%), and lesions <10 mm accounted for 87% of the cases. Endoscopic submucosal resection with a ligation device (ESMR‐L, 56.5%) was the most common method, followed by endoscopic submucosal dissection (ESD, 31.4%) and endoscopic mucosal resection using a cap (EMR‐C, 8.5%). R0 resection rates <10 mm were 95.5%, 94.8%, and 94.3% for ESMR‐L, ESD, and EMR‐C, respectively. All 16 (3.8%) patients who developed treatment‐related complications could be treated conservatively. Overall, 23 (5.5%) patients had incomplete resection without independent clinicopathological risk factors. Conclusion: ESMR‐L, ESD, and EMR‐C were equally effective and safe for colorectal NETs with a diameter <10 mm. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09155635
Volume :
36
Issue :
8
Database :
Complementary Index
Journal :
Digestive Endoscopy
Publication Type :
Academic Journal
Accession number :
178910341
Full Text :
https://doi.org/10.1111/den.14728