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The prognostic impact of follow-up cardiac metaiodobenzylguanidine imaging on left ventricular trajectory after acute decompensation.

Authors :
Kayama, Kiyomi
Yamada, Takahisa
Seo, Masahiro
Watanabe, Tetsuya
Morita, Takashi
Kawasaki, Masato
Kikuchi, Atsushi
Kawai, Tsutomu
Nakamura, Jun
Fukunami, Masatake
Source :
European Heart Journal - Cardiovascular Imaging; Aug2024, Vol. 25 Issue 8, p1144-1154, 11p
Publication Year :
2024

Abstract

Aims Cardiac metaiodobenzylguanidine (MIBG) imaging provides prognostic information in patients with heart failure (HF). Recently, the trajectory of left ventricular ejection fraction (LVEF) has been a focus in patients with reduced LVEF admitted for acute decompensated HF (ADHF). We sought to investigate the prognostic value of follow-up cardiac MIBG imaging in ADHF patients with reduced LVEF in relation to LVEF trajectory. Methods and results We prospectively studied 145 ADHF patients with a reduced LVEF of <40%. The cardiac MIBG heart-to-mediastinum ratio (the late HMR) was measured on the delayed image at discharge and at the 6-month follow-up (6FUP). At 6 months after discharge, 54 (37%) patients had complete recovery of LVEF ≥50% (HFcorEF), and 43 (30%) patients had partial recovery of LVEF 40–50% (HFparEF), while the remaining 48 (33%) patients had no functional recovery of LVEF (HFnorEF). The late HMR at the 6FUP in HFcorEF patients was significantly greater than that in HFparEF and HFnorEF patients. During a follow-up period of 4.3 ± 2.6 years, 43 patients had cardiac events, defined as a composite of readmission for worsening HF and cardiac death. Patients with a lower late HMR at the 6FUP had a greater risk of cardiac events than those with a higher late HMR at the 6FUP in the group with recovered LVEF, especially HFparEF, which was not observed in the HFnorEF subgroup. Conclusion Follow-up MIBG imaging after discharge could provide additional prognostic information in ADHF patients with recovered left ventricular function. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20472404
Volume :
25
Issue :
8
Database :
Complementary Index
Journal :
European Heart Journal - Cardiovascular Imaging
Publication Type :
Academic Journal
Accession number :
178887414
Full Text :
https://doi.org/10.1093/ehjci/jeae077