Time Restricted Feeding: Implications to Healthy Well-Being.

Circadian rhythmicity optimizes the health and physiology by coordinating temporally the cellular functions, tissue functions, and behavior. These endogenously generated rhythms gets dampen with age and therefore compromise the temporal coordination. The pattern of fasting and feeding sets an external cue that profoundly influences the robustness of daily circadian rhythms. Irregular eating patterns can change the temporal coordination of physiology and metabolism leading to chronic diseases. Robust sustaining of fasting and feeding cycle, without altering nutrition quality, can reverse or prevent the chronic diseases as already depicted in an animal model. However, in humans, studies have shown that erratic pattern of eating can elevate the risk of diseases, whereas sustained fasting and feeding cycle, or prolonged overnight fasting, is correlated with protection from different cancers. Therefore, by just optimizing the external cues timing well defined eating patterns, can thus sustain a robust circadian clock, which may result in preventing many diseases and can improve the prognosis. Time-restricted feeding (TRF) is a form of intermittent fasting, comprising a longer daily fasting period. Preliminary studies report that TRF improves cardiometabolic diseases, diabetes and cancer in rodents and humans. [ABSTRACT FROM AUTHOR]