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Is a long-term ranitidine-based triple therapy against.
- Source :
- Alimentary Pharmacology & Therapeutics; Aug2005, Vol. 22 Issue 4, p343-348, 6p
- Publication Year :
- 2005
-
Abstract
- Acid suppression plus two antibiotics is currently considered the gold standard anti- Helicobacter pylori treatment, but the effective role of gastric antisecretory drugs is still poorly understood. To compare a 14-day ranitidine-based triple regimen against Helicobacter pylori with one based on omeprazole, and to study the influence of antisecretory drugs on metronidazole pharmacokinetics in human plasma. A total of 150 dyspeptic H. pylori-infected patients were randomized for ranitidine 300 mg b.d. (RCM group) or omeprazole 20 mg b.d. (OCM group) 14-day triple therapy, with clarithromycin 500 mg b.d. and metronidazole 500 mg b.d. On the eighth day of therapy, metronidazole pharmacokinetics was studied in plasma by high-performance liquid chromatography. The pharmacokinetic parameters (terminal half-life, area under the curve, peak-plasma level, peak time) of metronidazole were computed using standard non-compartmental methods. H. pylori status was monitored before and 4 weeks after the end of therapy by histology, serology and rapid urease test. On an intention-to-treat basis, eradication rates were 91 and 76% for the RCM and OCM groups respectively ( P < 0.02). Significantly different pharmacokinetic parameters of metronidazole were found between the groups: peak-plasma level ( P < 0.01) and area under the curve ( P < 0.02). Our results show that the RCM regimen was more effective than that based on OCM and that the antisecretory drugs affected metronidazole availability, increasing the efficacy of ranitidine-based regimens. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02692813
- Volume :
- 22
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Alimentary Pharmacology & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 17879381
- Full Text :
- https://doi.org/10.1111/j.1365-2036.2005.02575.x