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Variation of subclinical psychosis across 16 sites in Europe and Brazil: findings from the multi-national EU-GEI study.
- Source :
- Psychological Medicine; Jun2024, Vol. 54 Issue 8, p1810-1823, 14p
- Publication Year :
- 2024
-
Abstract
- Background: Incidence of first-episode psychosis (FEP) varies substantially across geographic regions. Phenotypes of subclinical psychosis (SP), such as psychotic-like experiences (PLEs) and schizotypy, present several similarities with psychosis. We aimed to examine whether SP measures varied across different sites and whether this variation was comparable with FEP incidence within the same areas. We further examined contribution of environmental and genetic factors to SP. Methods: We used data from 1497 controls recruited in 16 different sites across 6 countries. Factor scores for several psychopathological dimensions of schizotypy and PLEs were obtained using multidimensional item response theory models. Variation of these scores was assessed using multi-level regression analysis to estimate individual and between-sites variance adjusting for age, sex, education, migrant, employment and relational status, childhood adversity, and cannabis use. In the final model we added local FEP incidence as a second-level variable. Association with genetic liability was examined separately. Results: Schizotypy showed a large between-sites variation with up to 15% of variance attributable to site-level characteristics. Adding local FEP incidence to the model considerably reduced the between-sites unexplained schizotypy variance. PLEs did not show as much variation. Overall, SP was associated with younger age, migrant, unmarried, unemployed and less educated individuals, cannabis use, and childhood adversity. Both phenotypes were associated with genetic liability to schizophrenia. Conclusions: Schizotypy showed substantial between-sites variation, being more represented in areas where FEP incidence is higher. This supports the hypothesis that shared contextual factors shape the between-sites variation of psychosis across the spectrum. [ABSTRACT FROM AUTHOR]
- Subjects :
- SCHIZOTYPAL personality disorder
ECOLOGY
RESEARCH funding
MULTIPLE regression analysis
SEX distribution
NOMADS
SOCIOECONOMIC factors
DESCRIPTIVE statistics
AGE distribution
RESEARCH
MATHEMATICAL models
PSYCHOSES
THEORY
COMPARATIVE studies
CANNABIS (Genus)
SOCIODEMOGRAPHIC factors
PHENOTYPES
DISEASE incidence
ADVERSE childhood experiences
EMPLOYMENT
Subjects
Details
- Language :
- English
- ISSN :
- 00332917
- Volume :
- 54
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Psychological Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 178781961
- Full Text :
- https://doi.org/10.1017/S0033291723003781