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Polygenic risk for schizophrenia predicting social trajectories in a general population sample.

Authors :
Saarinen, Aino
Hietala, Jarmo
Lyytikäinen, Leo-Pekka
Hamal Mishra, Binisha
Sormunen, Elina
Lavonius, Veikka
Kähönen, Mika
Raitakari, Olli
Lehtimäki, Terho
Keltikangas-Järvinen, Liisa
Source :
Psychological Medicine; Jun2024, Vol. 54 Issue 8, p1589-1597, 9p
Publication Year :
2024

Abstract

Background: We investigated (a) whether polygenic risk for schizophrenia predicts different trajectories of social development among those who have not developed psychoses and (b) whether possible associations are PRS<subscript>SCZ</subscript>-specific or evident also for any polygenic risk for mental disorders, e.g. for major depression. Methods: Participants came from the population-based Young Finns Study (n = 2377). We calculated a polygenic risk score for schizophrenia (PRS<subscript>SCZ</subscript>) and for major depression (PRS<subscript>DEP</subscript>). Diagnoses of psychotic disorders were derived from the hospital care register. Social development from adolescence to middle age was measured by (a) perceived social support from friends, family, and a close other, (b) perceived sociability, and (c) family structure (partnership status, number of children, age of first-time parenthood). Results: Among those without manifest psychoses, high PRS<subscript>SCZ</subscript> predicted lower experienced support from friends (B = −0.04, p = 0.009–0.035) and family (B = −0.04, p = 0.009–0.035) especially after early adulthood, and also lower perceived sociability (B = −0.05, p = 0.010–0.026). PRS<subscript>SCZ</subscript> was not related to family structure. PRS<subscript>DEP</subscript> did not predict any domain of social development. Conclusions: Individuals at high PRS<subscript>SCZ</subscript> (not converted to psychosis) seem to experience a lower preference to be with others over being alone. Individuals with high (v. low) PRS<subscript>SCZ</subscript> seem to have a similar family structure in terms of partnership status or number of children but, nevertheless, they experience less support from their family. Among those not converted to psychosis in a typical age period, high PRS<subscript>SCZ</subscript> may predict a 'later risk phase' and reduced functional resilience when approaching middle age. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00332917
Volume :
54
Issue :
8
Database :
Complementary Index
Journal :
Psychological Medicine
Publication Type :
Academic Journal
Accession number :
178781939
Full Text :
https://doi.org/10.1017/S003329172300346X