New Lung Cancer Study Findings Have Been Reported by Investigators at Tohoku University (Dipeptidyl Peptidase 4-positive Cancer-associated Fibroblasts Enhance Lung Adenocarcinoma Growth).

Researchers at Tohoku University in Sendai, Japan have conducted a study on lung adenocarcinoma (LUAD) and its association with cancer-associated fibroblasts (CAFs) that express dipeptidyl peptidase 4 (DPP4). The study found that patients with DPP4-positive CAFs had higher levels of tumor cell proliferation and expression of certain markers compared to those with DPP4-negative CAFs. In vitro experiments also showed that DPP4-positive CAFs promoted the growth of LUAD cells and increased the production of certain cytokines. The researchers suggest that inhibiting DPP4 could potentially inhibit the progression of lung adenocarcinoma. [Extracted from the article]