Reports from University of Science and Technology of China (USTC) Describe Recent Advances in Osteophyte (Human Infrapatellar Fat Pad Mesenchymal Stem Cell-derived Extracellular Vesicles Purified By Anion Exchange Chromatography Suppress...).

A recent study conducted by researchers at the University of Science and Technology of China (USTC) explores the potential of using extracellular vesicles derived from mesenchymal stem cells (MSCs) to treat osteoarthritis (OA). The study focuses on the clinical feasibility of using an accessible cell source and a scalable preparation method for MSC-extracellular vesicles. The researchers found that infrapatellar fat pads obtained from patients undergoing total knee arthroplasty (TKA) can serve as a suitable cell source for producing MSC-extracellular vesicles, and anion exchange chromatography is effective for isolating these vesicles. In an animal model of OA, the injection of MSC-extracellular vesicles was found to alleviate pain, suppress cartilage degeneration, inhibit osteophyte formation, and reduce synovial inflammation. The autologous origin of the extracellular vesicles and the scalable purification method make this strategy potentially viable for clinical translation. [Extracted from the article]