The effect of Vitamin D (1,25-(OH)2-D3) on human theca and granulosa cell function. (Updated July 23, 2024).

A preprint abstract from biorxiv.org discusses the potential link between Vitamin D deficiency and reproductive outcomes. The study explores the effect of deficient levels of 1,25-(OH)2-D3, a form of Vitamin D, on ovarian cell function. The researchers found that low levels of 1,25-(OH)2-D3 may impair ovarian cell function and potentially affect folliculogenesis/ovulation. However, the impact of mild deficiency may be less significant, except in the presence of hyperinsulinemia and insulin resistance. The study also highlights the unique challenges of obtaining human thecal and unluteinised granulosa cells for research purposes. It is important to note that this preprint has not yet undergone peer review. [Extracted from the article]