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PRRT with Lu-177 DOTATATE in Treatment-Refractory Progressive Meningioma: Initial Experience from a Tertiary-Care Neuro-Oncology Center.

PRRT with Lu-177 DOTATATE in Treatment-Refractory Progressive Meningioma: Initial Experience from a Tertiary-Care Neuro-Oncology Center.

Authors :
Puranik, Ameya D.
Dev, Indraja D.
Rangarajan, Venkatesh
Kulkarni, Suyash
Shetty, Nitin
Gala, Kunal
Sahu, Arpita
Bhattacharya, Kajari
Dasgupta, Archya
Chatterjee, Abhishek
Gupta, Tejpal
Sridhar, Epari
Sahay, Ayushi
Shetty, Prakash
Singh, Vikas
Moiyadi, Aliasgar
Menon, Nandini
Purandare, Nilendu C.
Agrawal, Archi
Shah, Sneha
Source :
Neurology India; Mar/Apr2024, Vol. 72 Issue 2, p278-284, 7p
Publication Year :
2024

Abstract

Purpose: Refractory and/or recurrent meningiomas have poor outcomes, and the treatment options are limited. Peptide receptor radionuclide therapy (PRRT) has been used in this setting with promising results. We have documented our experience of using intravenous (IV) and intra-arterial (IA) approaches of Lu-177 DOTATATE PRRT. Methods: Eight patients with relapsed/refractory high-grade meningioma received PRRT with Lu-177 DOTATATE by IV and an IA route. At least 2 cycles were administered. Time to progression was calculated from the first PRRT session to progression. The response was assessed on MRI using RANO criteria, and visual analysis of uptake was done on Ga-68 DOTANOC PET/CT. Post-therapy dosimetry calculations for estimating the absorbed dose were performed. Results: Median time to progression was 8.9 months. One patient showed disease progression, whereas seven patients showed stable disease at 4 weeks following 2 cycles of PRRT. Dosimetric analysis showed higher dose and retention time by IA approach. No significant peri-procedural or PRRT associated toxicity was seen. Conclusion: PRRT is a safe and effective therapeutic option for relapsed/refractory meningioma. The IA approach yields better dose delivery and should be routinely practised. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00283886
Volume :
72
Issue :
2
Database :
Complementary Index
Journal :
Neurology India
Publication Type :
Academic Journal
Accession number :
178746956
Full Text :
https://doi.org/10.4103/NI.Neurol-India-D-23-00252