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A Role for Platelet-Derived Growth Factor in Drug-Induced Chronic Ergotism?
- Source :
- Angiology; Jul1995, Vol. 46 Issue 7, p633-636, 4p
- Publication Year :
- 1995
-
Abstract
- Generalized vasoconstriction in chronic ergot poisoning is attributed both to the ergotamine activity on a-adrenergic receptors and to its direct action on vascular smooth muscle cells. The authors propose that endothelial wall, chronically damaged by ergot alkaloids, releases platelet-derived growth factor (PDGF), which contributes to vasoconstriction and promotes further arterial obstruction. Their hypothesis is supported by the increased PDGF activity found in plasma of a patient suffering from chronic ergotism. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 46
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 17870187
- Full Text :
- https://doi.org/10.1177/000331979504600712