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Does Preterm Prolonged Rupture of Membranes Increase the Risk of Needing Invasive Respiratory Support? A Retrospective Single-Centre Study.
- Source :
- Children; Jul2024, Vol. 11 Issue 7, p823, 6p
- Publication Year :
- 2024
-
Abstract
- (1) Background: Preterm premature rupture of membranes (PPROM) has been associated with increased perinatal morbidity, but the effect of PPROM on respiratory disease has not been previously quantified. We hypothesised that PPROM would be associated with a higher incidence of invasive ventilation. (2) Methods: A retrospective cohort study at the Neonatal Unit at King's College Hospital NHS Foundation Trust, London, UK, was conducted on infants born before 37 weeks of gestation. PPROM was defined as the rupture of membranes for >48 h. (3) Results: We reviewed 1901 infants (434 with PPROM) with a median (IQR) gestational age of 32.4 (28.7–35.0) weeks. The median (IQR) duration of rupture of membranes in the infants with PPROM was 129 (78–293) h. The incidence of invasive ventilation was 56% in the infants with PPROM and 46% in the infants without PPROM (p < 0.001). Following regression analysis, PPROM was significantly related to a higher incidence of invasive ventilation (odds ratio: 1.48; 95% CI: 1.13–1.92, adjusted p = 0.004) after adjusting for birth weight [odds ratio = 0.34; 95% CI: 0.33–0.43, adjusted p < 0.001], Apgar score at 10 min [odds ratio =0.61; 95% CI: 0.56–0.66, adjusted p < 0.001] and antenatal corticosteroid use (adjusted p = 0.939). (4) Conclusions: PPROM was associated with a 1.48-fold higher risk of needing invasive ventilation. [ABSTRACT FROM AUTHOR]
- Subjects :
- TREATMENT of respiratory diseases
RISK assessment
ADRENOCORTICAL hormones
CESAREAN section
ACADEMIC medical centers
MATERNAL age
PATIENTS
DATA analysis
INFANT mortality
SEX distribution
HOSPITAL admission & discharge
RETROSPECTIVE studies
CHI-squared test
MANN Whitney U Test
DESCRIPTIVE statistics
OPERATIVE surgery
LONGITUDINAL method
HOSPITAL care of newborn infants
ODDS ratio
PRENATAL care
ARTIFICIAL respiration
MEDICAL records
ACQUISITION of data
APGAR score
GESTATIONAL age
STATISTICS
PREGNANCY complications
CONFIDENCE intervals
COMPARATIVE studies
BIRTH weight
MEDICAL thermometry
DATA analysis software
RESPIRATORY distress syndrome
TIME
DISEASE incidence
NONPARAMETRIC statistics
REGRESSION analysis
DISEASE complications
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 22279067
- Volume :
- 11
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Children
- Publication Type :
- Academic Journal
- Accession number :
- 178695107
- Full Text :
- https://doi.org/10.3390/children11070823