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Predicting T-Cell Lymphoma in Children From 18F-FDG PET-CT Imaging With Multiple Machine Learning Models.
- Source :
- Journal of Digital Imaging; Jun2024, Vol. 37 Issue 3, p952-964, 13p
- Publication Year :
- 2024
-
Abstract
- This study aimed to examine the feasibility of utilizing radiomics models derived from <superscript>18</superscript>F-FDG PET/CT imaging to screen for T-cell lymphoma in children with lymphoma. All patients had undergone <superscript>18</superscript>F-FDG PET/CT scans. Lesions were extracted from PET/CT and randomly divided into training and validation sets. Two different types of models were constructed as follows: features that are extracted from standardized uptake values (SUV)-associated parameters, and CT images were used to build SUV/CT-based model. Features that are derived from PET and CT images were used to build PET/CT-based model. Logistic regression (LR), linear support vector machine, support vector machine with the radial basis function kernel, neural networks, and adaptive boosting were performed as classifiers in each model. In the training sets, 77 patients, and 247 lesions were selected for building the models. In the validation sets, PET/CT-based model demonstrated better performance than that of SUV/CT-based model in the prediction of T-cell lymphoma. LR showed highest accuracy with 0.779 [0.697, 0.860], area under the receiver operating characteristic curve (AUC) with 0.863 [0.762, 0.963], and preferable goodness-of-fit in PET/CT-based model at the patient level. LR also showed best performance with accuracy of 0.838 [0.741, 0.936], AUC of 0.907 [0.839, 0.976], and preferable goodness-of-fit in PET/CT-based model at the lesion level. <superscript>18</superscript>F-FDG PET/CT-based radiomics models with different machine learning classifiers were able to screen T-cell lymphoma in children with high accuracy, AUC, and preferable goodness-of-fit, providing incremental value compared with SUV-associated features. [ABSTRACT FROM AUTHOR]
- Subjects :
- T-cell lymphoma
RADIOPHARMACEUTICALS
DIAGNOSTIC imaging
PREDICTION models
RESEARCH funding
TUMORS in children
DEOXY sugars
EARLY detection of cancer
RADIOMICS
COMPUTED tomography
STATISTICAL sampling
LOGISTIC regression analysis
DESCRIPTIVE statistics
SUPPORT vector machines
COMPUTERS in medicine
RESEARCH methodology
ARTIFICIAL neural networks
MACHINE learning
COMPARATIVE studies
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 08971889
- Volume :
- 37
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Digital Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 178678168
- Full Text :
- https://doi.org/10.1007/s10278-024-01007-y