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Flexible adaptive sensing tonometry for medical-grade multi-parametric hemodynamic monitoring.

Authors :
Deng, Mengkang
Du, Chentao
Fang, Jiayuan
Xu, Changshun
Guo, Chenhui
Huang, Jiantao
Li, Kang
Chen, Lei
Zhang, Yuan-Ting
Chang, Yu
Pan, Tingrui
Source :
NPJ Flexible Electronics; 7/27/2024, Vol. 8 Issue 1, p1-16, 16p
Publication Year :
2024

Abstract

Continuous hemodynamic monitoring in a wearable means can play a crucial role in managing hypertension and preventing catastrophic cardiovascular events. In this study, we have described the fully wearable tonometric device, referred to as flexible adaptive sensing tonometry (FAST), which is capable of continuous and accurate monitoring of hemodynamic parameters within the medical-grade precision. In particular, the FAST system integrates a 1 × 8 unit array of highly sensitive and highly flexible iontronic sensing (FITS) with 1 mm spatial resolution and a closed-loop motion system. The flexible tonometric architecture has been used to determine the radial arterial position with high sensitivity and high conformability, which simplifies the biaxial searching process of the traditional applanation tonometry into a highly efficient uniaxial applanation while keeping the medical-precision assessments. Importantly, a self-calibration algorithm can be automatically implemented during the applanation process, from which the intra-arterial blood pressure wave can be continuously predicted within the medical-grade precision, and subsequently, multi-parametric hemodynamic analysis can be performed in real-time. Experimental validations on health volunteers have demonstrated that the FAST measurements are all within the required accuracy of the clinical standards for continuous pulse wave assessments, blood pressure monitoring as well as other key hemodynamic parameter evaluations. Therefore, the FAST system, by integrating the flexible iontronic sensing array, provides a real-time, medical-grade hemodynamic monitoring solution in a continuously wearable manner, from which remote patient-centered monitoring can be delivered with both medical precision and convenience. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23974621
Volume :
8
Issue :
1
Database :
Complementary Index
Journal :
NPJ Flexible Electronics
Publication Type :
Academic Journal
Accession number :
178655359
Full Text :
https://doi.org/10.1038/s41528-024-00329-9