Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology.

The article discusses the need for a shift in regulatory toxicology from animal testing to New Approach Methods (NAMs). The authors introduce the "CHANGE" project, which aims to promote the use of NAMs through system-level interventions. The project takes an interdisciplinary approach and involves stakeholders from various sectors and countries. The article outlines the methodology of the project and highlights the challenges and opportunities associated with implementing NAMs. It emphasizes the importance of inclusive participation and collaboration to overcome these challenges and promote the use of NAMs. [Extracted from the article]