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Evaluating the relationship between hepatitis B viral activity and gestational diabetes mellitus: A prospective cohort study.
- Source :
- Women's Health (17455057); 7/25/2024, p1-10, 10p
- Publication Year :
- 2024
-
Abstract
- Background: Hepatitis B infection has been associated with the development of gestational diabetes but the underlying mechanism is not known. Objective: To examine associations between viral activity, gestational diabetes mellitus (GDM), and insulin resistance in pregnant people with chronic hepatitis B infection (HBV). Design: Prospective cohort study across three tertiary maternity centres in Melbourne, Australia, between May 2021 and April 2023. Methods: Participants were followed prospectively through pregnancy to evaluate subsequent GDM diagnosis. Demographics, pregnancy outcomes, and markers of viral activity were compared between those with GDM versus those without. Logistic regression analysis was performed pre- and post-adjustment for known confounders. Sub-group analysis of participants from South East Asia (SEA) was performed. Outcome measures included GDM diagnosis, insulin resistance (Homeostatic Model Assessment Insulin Resistance score (HOMA-IR) score), HBV activity as measured by liver function tests, HBV viral load, hepatitis B e antigen, and quantitative hepatitis B surface antigen (quantHBsAg). Results: A total of 113 women were recruited. One third (38/112, 33.9%) developed GDM, mostly diagnosed on isolated postprandial hyperglycaemia (25/38, 65.8%). Over half were born in SEA (66/113, 58.4%). Mean quantHBsAg was significantly lower in those with GDM (p = 0.044). No other associations were identified between GDM or HOMA-IR and markers of hepatic activity on multivariate logistic regression analysis and on sub-group analysis of those born in SEA. Conclusions: QuantHBsAg was significantly lower in those with GDM; otherwise, no association between GDM and measures of HBV viral activity was found. QuantHBsAg may be useful as an early pregnancy marker for GDM risk and warrants further research. [ABSTRACT FROM AUTHOR]
- Subjects :
- COMMUNICABLE diseases
RISK assessment
VIRAL load
T-test (Statistics)
STATISTICAL significance
RESEARCH funding
GESTATIONAL diabetes
MULTIPLE regression analysis
CHRONIC hepatitis B
TERTIARY care
MULTIVARIATE analysis
CHI-squared test
DESCRIPTIVE statistics
INSULIN resistance
LONGITUDINAL method
ANTIGENS
ODDS ratio
PREGNANCY complications
CONFIDENCE intervals
DATA analysis software
LIVER function tests
EVALUATION
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 17455057
- Database :
- Complementary Index
- Journal :
- Women's Health (17455057)
- Publication Type :
- Academic Journal
- Accession number :
- 178652887
- Full Text :
- https://doi.org/10.1177/17455057241265083