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Gastric adenosquamous carcinoma producing granulocyte-colony stimulating factor.
- Source :
- Gastric Cancer; Sep2005, Vol. 8 Issue 3, p173-177, 5p
- Publication Year :
- 2005
-
Abstract
- We report a case of adenosquamous carcinoma of the stomach that produced granulocyte-colony stimulating factor (G-CSF). The patient, who had an admission diagnosis of advanced gastric cancer, had marked leukocytosis without evidence of infection. After leukemia and metastatic leukemoid reaction were excluded by bone marrow examination, a G-CSF-producing cancer was suspected as the cause of the abnormally elevated serum G-CSF level. The resected stomach tumor was histologically diagnosed as adenosquamous carcinoma; positive expression of G-CSF by tumor cells was shown with immunohistochemical detection, which confirmed the preoperative diagnosis. Recurrent disease in the liver and lymph nodes, accompanied by leukocytosis and re-elevation of serum G-CSF, developed just 3 months after the curative gastrectomy and adjuvant chemotherapy. All of the recurrent disease was resected, restoring normal levels of serum G-CSF. The patient survived for almost 2 years after the initial surgery with extensive chemotherapy, including weekly treatment with paclitaxel, before finally succumbing to liver failure secondary to extensive liver metastasis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14363291
- Volume :
- 8
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Gastric Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 17863482
- Full Text :
- https://doi.org/10.1007/s10120-005-0330-y