Study Results from Aligarh Muslim University in the Area of Phenylpiperazine Antidepressants Reported (Statistical Design Approach for Optimizing the Spectrofluorimetric Method for Quantifying Trazodone Hydrochloride).

A study conducted at Aligarh Muslim University in Uttar Pradesh, India, has developed a sensitive spectrofluorimetric method for quantifying trazodone hydrochloride in its formulation and urine samples. The method involves the formation of an ion pair complex between the drug and eosin Y, followed by fluorescence measurement. The method was found to be accurate and precise, with good recovery rates and no interference from common excipients. The research concluded that the developed method can successfully determine trazodone in urine samples. [Extracted from the article]