University of Bari 'Aldo Moro' Researchers Update Current Data on Oxaliplatin Therapy [Interactions with DNA Models of the Oxaliplatin Analog (cis -1,3-DACH)PtCl [ [2] ]].

Fresh data on oxaliplatin therapy is presented in a new report from researchers at the University of Bari 'Aldo Moro' in Italy. The study investigates the effect of the carrier ligand cis-1,3-diaminocyclohexane (cis-1,3-DACH) on the formation, stability, and stereochemistry of the (cis-1,3-DACH)PtG and (cis-1,3-DACH)Pt(d(GpG)) adducts. The research concludes that the (cis-1,3-DACH)Pt(d(GpG)) adduct is present in two isomeric forms, with a dominance of the HH conformer but with some contribution of the DHT conformer. This study provides valuable insights into the interactions of oxaliplatin analogs with DNA models. [Extracted from the article]