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Silver/gold nanoalloy implant coatings with antibiofilm activity via pH-triggered silver ion release.

Authors :
Geissel, Felix J.
Platania, Varvara
Tsikourkitoudi, Vasiliki
Larsson, Justina Venckute
Thersleff, Thomas
Chatzinikolaidou, Maria
Sotiriou, Georgios A.
Source :
Chemical Communications; 8/4/2024, Vol. 60 Issue 60, p7729-7732, 4p
Publication Year :
2024

Abstract

Implant infections are a major challenge for the healthcare system. Biofilm formation and increasing antibiotic resistance of common bacteria cause implant infections, leading to an urgent need for alternative antibacterial agents. In this study, the antibiofilm behaviour of a coating consisting of a silver (Ag)/gold (Au) nanoalloy is investigated. This alloy is crucial to reduce uncontrolled potentially toxic Ag<superscript>+</superscript> ion release. In neutral pH environments this release is minimal, but the Ag<superscript>+</superscript> ion release increases in acidic microenvironments caused by bacterial biofilms. We perform a detailed physicochemical characterization of the nanoalloys and compare their Ag<superscript>+</superscript> ion release with that of pure Ag nanoparticles. Despite a lower released Ag<superscript>+</superscript> ion concentration at pH 7.4, the antibiofilm activity against Escherichia coli (a bacterium known to produce acidic pH environments) is comparable to a pure nanosilver sample with a similar Ag-content. Finally, biocompatibility studies with mouse pre-osteoblasts reveal a decreased cytotoxicity for the alloy coatings and nanoparticles. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13597345
Volume :
60
Issue :
60
Database :
Complementary Index
Journal :
Chemical Communications
Publication Type :
Academic Journal
Accession number :
178594381
Full Text :
https://doi.org/10.1039/d4cc01168f