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Secrets of DNA-PKcs beyond DNA repair.
- Source :
- NPJ Precision Oncology; 7/23/2024, Vol. 8 Issue 1, p1-14, 14p
- Publication Year :
- 2024
-
Abstract
- The canonical role of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in repairing DNA double-strand breaks combined with its reported dysregulation in several malignancies has driven the development of DNA-PKcs inhibitors as therapeutics. However, until recently the relationship between DNA-PKcs and tumorigenesis has been primarily investigated with regard to its role in non-homologous end joining (NHEJ) repair. Emerging research has uncovered non-canonical DNA-PKcs functions involved with transcriptional regulation, telomere maintenance, metabolic regulation, and immune signaling all of which may also impinge on tumorigenesis. This review mainly discusses these non-canonical roles of DNA-PKcs in cellular biology and their potential contribution to tumorigenesis, as well as evaluating the implications of targeting DNA-PKcs for cancer therapy. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2397768X
- Volume :
- 8
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- NPJ Precision Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 178594000
- Full Text :
- https://doi.org/10.1038/s41698-024-00655-1