Material of choice for non‐invasive treatment of dentin caries: An in vitro study using natural carious lesions.

Introduction: In community settings with limited dental personnel and equipment, and in an era when the aerosol transmission of infectious agents is on the rise, a non‐invasive approach to caries management is critical. To provide information on non‐invasive material selection, the aim of this study was to compare the remineralization effect of commonly used fluoride‐containing materials, adjunctive to the everyday use of fluoride toothpaste (F‐toothpaste), on primary tooth natural dentin caries. Methods: Fifty‐five specimens were randomly divided into five groups: 38% silver diamine fluoride (SDF), 5% fluoride varnish (F‐varnish), glass‐ionomer cement (GIC), deionized water (DW) with F‐toothpaste slurry, and DW as a control group (n = 11). The lesion depth and mineral density were measured before and after bacterial pH‐cycling using micro‐computed tomography. The percentage of mineral density change (%MDchange) was quantified. The dependent t‐test, Wilcoxon‐Signed‐Rank Test, and one way ANOVA with Bonferroni correction were used to analyse the data. Results: SDF application reduced lesion depth from 844.6 to 759.1 μm (p < 0.045) while increasing mineral density from 551.4 to 763.0 mgHA/cm3 (p < 0.003). Only mineral density rose from 600.2 to 678.4 mgHA/cm3 (p < 0.013) when GIC was used. The other groups showed no difference. The highest %MDchange was also found after SDF treatment (49.7%, p < 0.05), whereas GIC (17.2%, p < 0.05) presented a higher percentage than the F‐varnish (2.0%), F‐toothpaste (−1.1%) and no‐treatment groups (−1.4%). Conclusion: In this in vitro study, where the pH of cycling was almost neutral, using SDF as an adjunct to F‐toothpaste resulted in the highest remineralization compared with other remineralizing materials. [ABSTRACT FROM AUTHOR]