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Circular RNA IARS modulates the progression and ferroptosis of osteosarcoma via sponging miR-188-5p from RAB14.
- Source :
- Neoplasma; 2024, Vol. 71 Issue 3, p279-288, 10p
- Publication Year :
- 2024
-
Abstract
- Osteosarcoma (OS) is a common primary bone tumor in children and adolescents. Circular RNA (circRNA)-IARS acts as an oncogene in multiple human tumors. However, the circ-IARS function in OS is unclear. This research aimed to elucidate the roles and mechanisms of circ-IARS in OS. In this study, circ-IARS expressions were raised in OS tissues and cells. circ-IARS expressions were closely related to clinical stage and distant metastasis. Furthermore, overall survival rates were reduced in OS patients with high circ-IARS levels. Also, silencing circ-IARS weakened OS cell proliferation and invasion, yet enhanced cell ferroptosis. Mechanistically, circ-IARS targeted miR-188-5p to regulate RAB14 expressions in OS cells. Moreover, circ-IARS knockdown repressed OS cell proliferation, invasion, and induced ferroptosis, yet these impacts were abolished by co-transfection with anti-miR-188-5p or pcDNA-RAB14. Meanwhile, interference with circ-IARS reduced OS cell proliferation, and decreased RAB14 (a member of the RAS oncogene family), GPX4, and xCT (crucial ferroptosis regulators) expressions in vivo. In conclusion, circ-IARS facilitated OS progression via miR-188-5p/RAB14. [ABSTRACT FROM AUTHOR]
- Subjects :
- CIRCULAR RNA
MICRORNA
OSTEOSARCOMA
TUMORS in children
CELL proliferation
Subjects
Details
- Language :
- English
- ISSN :
- 00282685
- Volume :
- 71
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Neoplasma
- Publication Type :
- Academic Journal
- Accession number :
- 178548828
- Full Text :
- https://doi.org/10.4149/neo_2024_240312N111