A Mild Bilinear Synthesis Route of Broflanilide.

The Diamide insecticide Broflanilide acting on GABA receptor, which were developed by Mitsui Agricultural Chemical Company and BASF Corporation. A series of advantages led to their rapid promotion and application, such as high efficiency, low toxicity, and no cross resistance with traditional insecticides. Develop the synthesis route with warm reaction conditions and high yield to achieve the industrial production of Broflanilide by better route which is the focus of current pesticide workers. Based on the literature research results and the classic organic reactions, the synthesis route for Broflanilide were designed. Through a series of experiments, it is found that the target product can be gently and efficiently (38%) harvested under the catalysis of conventional inorganic salt potassium iodide (KI) by regulating the substitution order of functional groups and controlling the effect of steric hindrance on reactivity, which avoids the use of harsh conditions such as strong alkali low temperature or high boiling point solvent. [ABSTRACT FROM AUTHOR]