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Selective Enhancement of REM Sleep in Male Rats through Activation of Melatonin MT1 Receptors Located in the Locus Ceruleus Norepinephrine Neurons.
- Source :
- Journal of Neuroscience; 7/17/2024, Vol. 44 Issue 29, p1-16, 16p
- Publication Year :
- 2024
-
Abstract
- Sleep disorders affect millions of people around the world and have a high comorbidity with psychiatric disorders. While current hypnotics mostly increase non-rapid eye movement sleep (NREMS), drugs acting selectively on enhancing rapid eye movement sleep (REMS) are lacking. This polysomnographic study in male rats showed that the first-in-class selective melatonin MT<subscript>1</subscript> receptor partial agonist UCM871 increases the duration of REMS without affecting that of NREMS. The REMS-promoting effects of UCM871 occurred by inhibiting, in a dose–response manner, the firing activity of the locus ceruleus (LC) norepinephrine (NE) neurons, which express MT<subscript>1</subscript> receptors. The increase of REMS duration and the inhibition of LC-NE neuronal activity by UCM871 were abolished by MT<subscript>1</subscript> pharmacological antagonism and by an adeno-associated viral (AAV) vector, which selectively knocked down MT<subscript>1</subscript> receptors in the LC-NE neurons. In conclusion, MT<subscript>1</subscript> receptor agonism inhibits LC-NE neurons and triggers REMS, thus representing a novel mechanism and target for REMS disorders and/or psychiatric disorders associated with REMS impairments. [ABSTRACT FROM AUTHOR]
- Subjects :
- RAPID eye movement sleep
NON-REM sleep
NORADRENALINE
NEURONS
RATS
MELATONIN
Subjects
Details
- Language :
- English
- ISSN :
- 02706474
- Volume :
- 44
- Issue :
- 29
- Database :
- Complementary Index
- Journal :
- Journal of Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 178521349
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.0914-23.2024