Patent Issued for Methods, procedures and kits for providing maximum depth enrichment sequencing for identification for enrichment of rare genomic variants (USPTO 12024743).

New York University has been issued a patent for methods, procedures, and kits that provide maximum depth enrichment sequencing for the identification of rare genomic variants. Existing methods for detecting rare mutants in DNA sequences are expensive and inefficient. This patent addresses these deficiencies by introducing a method that utilizes barcoding techniques to decrease error rates and increase sensitivity in detecting rare genomic variants. The method involves digesting the nucleic acid, performing linear amplification with barcoded adapters, removing unused barcodes, performing mutant enrichment, and sequencing the resulting library. This patent offers a potential solution for improving the detection of rare genomic variants in cancer prognosis and other applications. [Extracted from the article]