DNA Origami Signal Amplification in LateralFlow Immunoassays.

A preprint abstract from biorxiv.org discusses a new technology that aims to improve the sensitivity of lateral flow immunoassays (LFIAs), which are paper-based tests used for rapid detection of analytes. The technology involves using DNA origami as an adapter to connect detection antibodies to signal-generating labels, resulting in a significant improvement in assay sensitivity. The researchers demonstrated this by applying the technology to detect cardiac troponin I in human serum. The DNA origami signal amplification technology is compatible with various analytes, labels, and sample matrices, making it a promising approach for enhancing the sensitivity and reliability of lateral flow testing. However, it is important to note that this research has not yet undergone peer review. [Extracted from the article]