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Ca2+ signaling and metabolic stress-induced pancreatic b-cell failure.
- Source :
- Frontiers in Endocrinology; 2024, p1-9, 9p
- Publication Year :
- 2024
-
Abstract
- Early in the development of Type 2 diabetes (T2D), metabolic stress brought on by insulin resistance and nutrient overload causes β-cell hyperstimulation. Herein we summarize recent studies that have explored the premise that an increase in the intracellular Ca<superscript>2+</superscript> concentration ([Ca<superscript>2+</superscript>]i), brought on by persistent metabolic stimulation of β-cells, causes β-cell dysfunction and failure by adversely affecting β-cell function, structure, and identity. This mini-review builds on several recent reviews that also describe how excess [Ca<superscript>2+</superscript>]i impairs β-cell function. [ABSTRACT FROM AUTHOR]
- Subjects :
- TYPE 2 diabetes
INSULIN resistance
Subjects
Details
- Language :
- English
- ISSN :
- 16642392
- Database :
- Complementary Index
- Journal :
- Frontiers in Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 178473251
- Full Text :
- https://doi.org/10.3389/fendo.2024.1412411