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Epidermal growth factor receptor‑targeted antibody nimotuzumab combined with chemoradiotherapy improves survival in patients with locally advanced head and neck squamous cell carcinoma: a propensity score matching real‐world study.

Authors :
Zhang, Peng
Zhang, Xinxin
Lang, Jinyi
Wu, Shaoxiong
Sun, Yan
Wang, Peiguo
Qiu, Sufang
Huang, Xiaodong
Ren, Guoxin
Liu, Kun
Du, Xiaojing
Xiao, Shaowen
Wang, Zhongqiu
Weng, Youliang
Zhang, Ye
Zhou, Hang
Tu, Wenyong
Zhang, Chenping
Yi, Junlin
Source :
MedComm; Jul2024, Vol. 5 Issue 7, p1-14, 14p
Publication Year :
2024

Abstract

Patients with locally advanced head and neck squamous cell carcinoma (LA‐HNSCC) have poor survival outcomes. The real‐world efficacy of nimotuzumab plus intensity modulated radiotherapy (IMRT)‐based chemoradiotherapy in patients with LA‐HNSCC remains unclear. A total of 25,442 HNSCC patients were screened, and 612 patients were matched by propensity score matching (PSM) (1:1). PSM was utilized to balance known confounding factors. Patients who completed at least five doses of nimotuzumab were identified as study group. The primary end point was 3‐year overall survival (OS) rate. Log‐rank test examined the difference between two survival curves and Cloglog transformation test was performed to compare survival at a fixed time point. The median follow‐up time was 54.2 (95% confidence interval [CI]: 52.7–55.9) months. The study group was associated with improved OS (hazard ratio [HR] = 0.75, 95% CI: 0.57–0.99, p = 0.038) and progression‐free survival (PFS) (HR = 0.74, 95% CI: 0.58–0.96, p = 0.021). Subgroup analysis revealed that aged 50–60 year, IV, N2, radiotherapy dose ≥ 60 Gy, without previous surgery, and neoadjuvant therapy have a trend of survival benefit with nimotuzumab. Nimotuzumab showed favorable safety, only 0.2% had nimotuzumab‐related severe adverse events. Our study indicated the nimotuzumab plus chemoradiotherapy provides survival benefits and safety for LA‐HNSCC patients in an IMRT era. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
26882663
Volume :
5
Issue :
7
Database :
Complementary Index
Journal :
MedComm
Publication Type :
Academic Journal
Accession number :
178469070
Full Text :
https://doi.org/10.1002/mco2.608