Sheep Placental Extract Improves Memory and Exercise Performance in Senescence- Accelerated Mice.

Traditional and folk medicine has used the placenta to treat a wide range of ailments. Fatigue is one of the frequent physiological reactions resulting from hard physical and mental work or severe life stress. The present study aimed to evaluate the effect of sheep placental extract (SPE) on memory and exercise performance in aged mice. Senescence-accelerated mouse prone-8 (SAMP8) was used as an ageing model and mice were fed with 3 (low, medium, and high) doses of SPE. Passive and active avoidance tests were performed to assess the memory function, treadmill exercise, forelimb grip strength test, liver glycogen and serum lactate were measured to assess the exercise performance. The memory of the aged mice was improved after SPE administration. Further, SPE treatment increased exercise performance by increasing forelimb grip strength and liver glycogen levels and decreasing serum lactate levels. To conclude, feeding sheep placental extract improves learning, memory, and exercise performance in ageing mice. [ABSTRACT FROM AUTHOR]