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The Roles of Non-coding RNA Targeting Astrocytes in Cerebral Ischemia.

Authors :
Long, Chun-mei
Li, Zhen
Song, Wang
Zeng, Xin
Yang, Rui
Lu, Li
Source :
Molecular Neurobiology; Aug2024, Vol. 61 Issue 8, p5814-5825, 12p
Publication Year :
2024

Abstract

Astrocytes are key targets for treating cerebral ischemia in the central nervous system. Non-coding RNAs (ncRNAs) participate in the pathological processes of astrocytes in cerebral ischemia. Recent reports suggest that ncRNAs ameliorate the outcome of cerebral ischemia by mediating astrocytes' inflammatory reaction, oxidative stress, excitotoxicity, autophagy, and apoptosis. Reconstructing cellular systems might offer a promising strategy for treating cerebral ischemia. This review briefly discusses the potential of ncRNAs as drug targets and explores the molecular regulatory mechanisms through which ncRNAs target astrocytes in cerebral ischemia. It provides an overview of the current research, discusses ncRNAs' implications as clinical markers for cerebral ischemia, and anticipates that ongoing research on ncRNAs may contribute to novel therapeutic approaches for treating this condition. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08937648
Volume :
61
Issue :
8
Database :
Complementary Index
Journal :
Molecular Neurobiology
Publication Type :
Academic Journal
Accession number :
178445387
Full Text :
https://doi.org/10.1007/s12035-023-03898-4