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Restored Cytokine-Producing Capacities of Mucosal-associated Invariant T Cells in Pediatric Cystic Fibrosis Patients Treated with Elexacaftor/Tezacaftor/Ivacaftor.

Authors :
Bardin, Emmanuelle
Dietrich, Céline
Attailia, Messaouda
Ferroni, Agnès
Jamet, Anne
Lezmi, Guillaume
Sermet-Gaudelus, Isabelle
Leite-de-Moraes, Maria
Source :
American Journal of Respiratory & Critical Care Medicine; 7/15/2024, Vol. 210 Issue 2, p243-245, 3p
Publication Year :
2024

Abstract

The article discusses how elexacaftor, tezacaftor, and ivacaftor (ETI) treatment restores the cytokine-producing abilities of mucosal-associated invariant T (MAIT) cells in pediatric cystic fibrosis (CF) patients. It shows that ETI significantly increases the number of MAIT cells and enhances their production of key cytokines like IFN-g, TNF-a, GrzB, and IL-17A. It is reported that this restoration may help improve infection control in CF patients by bolstering MAIT cell function.

Details

Language :
English
ISSN :
1073449X
Volume :
210
Issue :
2
Database :
Complementary Index
Journal :
American Journal of Respiratory & Critical Care Medicine
Publication Type :
Academic Journal
Accession number :
178439298
Full Text :
https://doi.org/10.1164/rccm.202401-0201LE