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New Findings from Gifu University Describe Advances in Biotechnology [Synthesis and Evaluation of 4'-c-(s) and 4'-c-(r)-2-aminopropoxy-thymidine-modified Dnas for Thermal Stability, Rnase H Digestion, and Nuclease...].
- Source :
- Gene Therapy Weekly; 7/19/2024, p1267-1267, 1p
- Publication Year :
- 2024
-
Abstract
- A new report from Gifu University in Japan discusses research on biotechnology and the development of antisense oligonucleotides (ASOs) as potential therapeutic agents for genetic disorders and life-threatening conditions. The researchers synthesized modified oligonucleotides containing new analogs and found that they exhibited improved stability and activity. These analogs also enhanced the serum stability of the modified oligodeoxynucleotides. The study concludes that these analogs have potential as ASO therapeutic candidates. The research has been peer-reviewed and published in ChemistrySelect. [Extracted from the article]
- Subjects :
- RIBONUCLEASE H
BIOTECHNOLOGY
THERMAL stability
DIGESTION
LIFE sciences
Subjects
Details
- Language :
- English
- ISSN :
- 10782842
- Database :
- Complementary Index
- Journal :
- Gene Therapy Weekly
- Publication Type :
- Periodical
- Accession number :
- 178391006