Patent Issued for Integration sites in CHO cells (USPTO 12018285).

A patent has been issued to Boehringer Ingelheim International GmbH for integration sites in Chinese hamster ovary (CHO) cells. The patent describes a method for stable integration of heterologous polynucleotides into the S100A gene cluster of the CHO cell genome, resulting in increased production of a heterologous gene product. This targeted integration approach eliminates the need for extensive screening procedures and allows for predictable and high-level production of biopharmaceutical proteins. The patent also includes claims for CHO cell lines and methods for their production. [Extracted from the article]