Research from Washington State University Broadens Understanding of Tumor Cell Line (AMPK Deficiency Increases DNA Methylation and Aggravates Colorectal Tumorigenesis in AOM/DSS Mice).

A recent report from Washington State University explores the relationship between AMP-activated protein kinase (AMPK) deficiency and colorectal cancer (CRC). The study found that AMPK deficiency accelerated CRC development in mice, leading to increased tumor number, size, and hyperplasia. This was associated with reduced production of a-ketoglutarate and ten-eleven translocation hydroxylase 2 (TET2) transcription, as well as downregulation of mismatch repair and tumor suppressor genes. The research suggests that AMPK activity could be a potential target for the prevention and treatment of CRC. [Extracted from the article]