Endothelial Zmiz1 modulates physiological and pathophysiological angiogenesis during retinal development.

According to a preprint abstract from biorxiv.org, researchers have discovered that a transcription cofactor called Zmiz1 plays a critical role in embryonic vascular development, postnatal retinal angiogenesis, and pathological angiogenesis in oxygen-induced retinopathy (OIR). In mice, the deletion of Zmiz1 in endothelial cells during embryogenesis led to abnormal angiogenesis and vascular defects, resulting in lethality. Furthermore, the ablation of Zmiz1 postnatally impaired retinal vascular outgrowth and decreased vascular density. The study suggests that Zmiz1 is essential for physiological and pathological angiogenesis. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]