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Unveiling myocardial microstructure shifts: exploring the impact of diabetes in stable CAD patients through CMR T1 mapping.
- Source :
- Diabetology & Metabolic Syndrome; 7/9/2024, Vol. 16 Issue 1, p1-8, 8p
- Publication Year :
- 2024
-
Abstract
- Background: This study investigates myocardial structural changes in stable coronary artery disease (CAD) patients with type 2 diabetes (T2D) using cardiac magnetic resonance (CMR) strain and T1 mapping. Methods: A total of 155 stable CAD patients underwent CMR examination, including left ventricular (LV) morphology and function assessment, late gadolinium enhancement (LGE), and feature tracking (CMR-FT) for LV global longitudinal, circumferential, and radial strain. T1 mapping with extracellular volume (ECV) evaluation was also performed. Results: Among the enrolled patients, 67 had T2D. Diabetic patients exhibited impaired LV strain and higher ECV compared to non-diabetics. Multivariate analysis identified T2D as an independent predictor of increased ECV and decreased strain. Conclusions: CMR-based strain and T1 mapping highlighted impaired myocardial contractility, elevated ECV, and potential interstitial fibrosis in diabetic patients with stable CAD. This suggests a significant impact of diabetes on myocardial health beyond CAD, emphasizing the importance of a comprehensive assessment in these individuals. Trial registration: http://www.controlled-trials.com/ISRCTN09454308 [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17585996
- Volume :
- 16
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Diabetology & Metabolic Syndrome
- Publication Type :
- Academic Journal
- Accession number :
- 178353851
- Full Text :
- https://doi.org/10.1186/s13098-024-01395-9