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Normal values of myocardial blood flow measured with dynamic myocardial computed tomography perfusion.
- Source :
- European Heart Journal - Cardiovascular Imaging; Jul2024, Vol. 25 Issue 7, p986-995, 10p
- Publication Year :
- 2024
-
Abstract
- Aims Dynamic myocardial computed tomography (CT) perfusion (DM-CTP) can, in combination with coronary CT angiography (CCTA), provide anatomical and functional evaluation of coronary artery disease (CAD). However, normal values of myocardial blood flow (MBF) are needed to identify impaired myocardial blood supply in patients with suspected CAD. We aimed to establish normal values for MBF measured using DM-CTP, to assess the effects of age and sex, and to assess regional distribution of MBF. Methods and results A total of 82 healthy individuals (46 women) aged 45–78 years with normal coronary arteries by CCTA underwent either rest and adenosine stress DM-CTP (n = 30) or adenosine-induced stress DM-CTP only (n = 52). Global and segmental MBF were assessed. Global MBF at rest and during stress were 0.93 ± 0.42 and 3.58 ± 1.14 mL/min/g, respectively. MBF was not different between the sexes (P = 0.88 at rest and P = 0.61 during stress), and no correlation was observed between MBF and age (P = 0.08 at rest and P = 0.82 during stress). Among the 16 myocardial segments, significant intersegmental differences were found (P < 0.01), which was not related to age, sex, or coronary dominance. Conclusion MBF assessed by DM-CTP in healthy individuals with normal coronary arteries displays significant intersegmental heterogeneity which does not seem to be affected by age, sex, or coronary dominance. Normal values of MBF may be helpful in the clinical evaluation of suspected myocardial ischaemia using DM-CTP. [ABSTRACT FROM AUTHOR]
- Subjects :
- CORONARY arterial radiography
REFERENCE values
SINGLE-photon emission computed tomography
BLOOD vessels
COMPUTED tomography
CORONARY circulation
SEX distribution
HEART function tests
SCIENTIFIC observation
POSITRON emission tomography
HEMODYNAMICS
AGE distribution
DESCRIPTIVE statistics
MANN Whitney U Test
PERFUSION imaging
LONGITUDINAL method
MYOCARDIUM
BLOOD flow measurement
PERFUSION
CORONARY angiography
Subjects
Details
- Language :
- English
- ISSN :
- 20472404
- Volume :
- 25
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- European Heart Journal - Cardiovascular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 178338085
- Full Text :
- https://doi.org/10.1093/ehjci/jeae050