Arginine Acts as both Co‐Solvent and Catalyst in Regioselective Eutectic‐Mediated Dimerization of Levulinic Acid.

A simple, solvent‐free arginine‐catalyzed aldol dimerization of levulinic acid was achieved via the simultaneous formation of a eutectic mixture. Dimers of levulinic acid are valued as biomass‐derived fine chemical precursors, with potential to upgrade to bio‐jet fuels or N‐containing functional chemicals. Typically, these dimers are produced as isomeric mixtures using high temperatures and a variety of solid inorganic catalysts or mineral acids. In this study, an organocatalytic and regioselective dimerization was achieved at 22 % conversion on either a bench or kilogram scale using mild temperatures and only L‐arginine as both a co‐solvent and catalyst. The intricate H‐bonding network comprising the eutectic solvent was harnessed to produce only one product, minimizing side reactivity and preserving the reactants for recycling. [ABSTRACT FROM AUTHOR]